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RESEARCH PRODUCT

Comparative chemical composition, free radical-scavenging and cytotoxic properties of essential oils of six Stachys species from different regions of the Mediterranean Area

Franco PiozziDaniela RiganoCarmen FormisanoFelice SenatoreFederica MenichiniFilomena ConfortiNelly Apostolides Arnold

subject

AntioxidantbiologyDPPHmedicine.medical_treatmentGeneral MedicineStachys cretica ssp vacillans S. germanica S. hydrophila S. nivea S. palustris S. spinosa Essential oil Antioxidant activity Cytotoxic activityStachysbiology.organism_classificationAnalytical Chemistrylaw.inventionchemistry.chemical_compoundchemistrylawBotanymedicineMediterranean areaCytotoxic T cellFood scienceChemical compositionScavengingEssential oilFood Science

description

Abstract The chemical composition of essential oils of six Stachys species, S. cretica L. ssp. vacillans Rech. fil., S. germanica L., S. hydrophila Boiss., S. nivea Labill., S. palustris L. and S. spinosa L., obtained by hydrodistillation, was studied by GC and GC–MS. All the oils have in common a great percentage of fatty acids and esters (24.2–58.5%) and a high amount of sesquiterpenes (16–35.9%), with the exception of the oil from S. palustris , which consisted mainly of carbonylic compounds (25.4%). The antioxidant activity by DPPH test and the antiproliferative activity on a series of human cancer cell lines (C32, amelanotic melanoma and ACHN, renal cell adenocarcinoma) were investigated for all the oils. S. palustris, S. cretica and S. hydrophila showed the highest antiradical effect, with IC 50 values of 0.482, 0.652 and 0.664 mg/ml, respectively. The most antiproliferative essential oil against C32 cell line was the oil of S. germanica with a 77% of inhibition at a concentration of 100 μg/ml. S. germanica , S. palustris and S. spinosa showed the most antiproliferative activity on ACHN cell line, at a concentration of 100 μg/ml,with 81%, 77% and 73% inhibition, respectively.

yearjournalcountryeditionlanguage
2009-10-15
10.1016/j.foodchem.2009.03.044http://hdl.handle.net/11588/351851