6533b7dbfe1ef96bd1271444

RESEARCH PRODUCT

Estradiol masculinizes the posteromedial cortical nucleus of the amygdala in the rat

Santiago SegoviaConcepción Vinader-caerolsAntonio GuillamonPaloma Collado

subject

Malemedicine.medical_specialtyVomeronasal organmedicine.drug_classCentral nervous systemCell CountBiologyAmygdalachemistry.chemical_compoundInternal medicineBasal gangliamedicineAnimalsOrchiectomyRats WistarTestosteroneNeuronsSex CharacteristicsEstradiolGeneral NeuroscienceAmygdalaRatsEndocrinologymedicine.anatomical_structureAnimals NewbornchemistryEstrogenEstradiol benzoateFemaleOrchiectomy

description

It has been demonstrated that the posteromedial cortical amygdaloid nucleus (PMCo), is sexually dimorphic. It is shown (Experiment 1) that male orchidectomy on the day of birth (D1) decreases the volume and number of neurons of the PMCo, while a single injection of propionate testosterone to the female on D1 masculinizes the PMCo in this gender. Since male gonadectomy on D1 (Experiment 2) is counteracted by a single injection of estradiol benzoate in males it has been suggested that the masculinization of the PMCo is due to the aromatization of testosterone to estradiol in this structure. These findings support the hypothesis that the development of sex differences in structures that belong to the vomeronasal system are due to the aromatization of testosterone to estradiol shortly after birth.

yearjournalcountryeditionlanguage
2000-10-01Brain Research Bulletin
https://doi.org/10.1016/s0361-9230(00)00332-4