6533b7dbfe1ef96bd12715e9

RESEARCH PRODUCT

Error calculation for the PSA quotient.

Borros M. Arneth

subject

Observational errorGaussianClinical BiochemistryNormal DistributionReproducibility of ResultsGeneral MedicineProstate-Specific Antigenurologic and male genital diseasesbehavioral disciplines and activitiessymbols.namesakeProstate-specific antigenmental disordersStatisticssymbolsHumansBiological AssayValue (mathematics)QuotientTotal psaMathematics

description

Abstract Objective Prostate specific antigen (PSA) assays have significant measurement errors, but the error associated with the PSA quotient (free to total PSA) often remains unknown. Methods We used both Gaussian error calculation and measurement of imprecision to investigate the level of error associated with the PSA quotient. Results Surprisingly, we found that the error of the PSA quotient at low levels is markedly smaller than that of the total PSA value. Conclusions The PSA quotient should be calculated and considered as a clinically relevant value.

yearjournalcountryeditionlanguage
2008-08-04Clinical biochemistry
10.1016/j.clinbiochem.2009.01.007https://pubmed.ncbi.nlm.nih.gov/19318034