Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group.

6533b7dbfe1ef96bd127160e

RESEARCH PRODUCT

Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group.

Carlos Del Pozo Antoni Riera Xavier Verdaguer Nuria Aiguabella Santos Fustero

subject

Models Molecular Trifluoromethyl Molecular Structure Chemistry Norbornadiene Pauson–Khand reaction Regioselectivity Stereoisomerism General Medicine General Chemistry Chemistry Techniques Synthetic Catalysis Adduct chemistry.chemical_compound Alkynes Structural isomer Organic chemistry Polycyclic Compounds Steering group Microwaves Sesquiterpenes Chlorofluorocarbons Methane

description

The reaction between alkynes (I) and norbornadiene (II) affords the β-substituted Pauson—Khand adducts (III) as single regioisomers and the trifluoromethyl steering group can be easily removed in the presence of DBU and water.

year	journal	country	edition	language
2013-04-10	Angewandte Chemie (International ed. in English)

10.1002/anie.201300907 https://pubmed.ncbi.nlm.nih.gov/23576241

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