6533b7dbfe1ef96bd127162a
RESEARCH PRODUCT
Inhibition of glial proliferation in vitro by serum from patients with multiple sclerosis
Donatella FerraroA. CestelliGiuseppe SalemiGiovanni SavettieriAlfredo Chiarinisubject
AdultMalemedicine.medical_specialtyPathologyMultiple SclerosisDiseaseBiologyTritiumSettore BIO/19 - Microbiologia GeneraleInternal medicineSettore BIO/10 - BiochimicamedicineAnimalsHumansCells CulturedFetusNeuroscience (all)Cell growthMultiple sclerosisGeneral MedicineMiddle Agedmedicine.diseaseIn vitroAcute stageRatsEndocrinologymedicine.anatomical_structureNeurologyCell cultureNeurogliaFemaleSettore MED/26 - NeurologiaNeurology (clinical)NeurogliaCell DivisionThymidinedescription
Primary cell cultures from fetal rat CNS have been employed to evaluate the effects caused by the addition of serum from patients affected by multiple sclerosis (MS). MS-serum supplemented media caused a decrease in [3H]-thymidine incorporation into the cultures, thus indicating an inhibitory effect on proliferating glial cells. Sera from patients in remission stage of the disease showed an inhibitory effect not significatively lower than those from patients in acute stage. These results suggest that glial cells may be a target of circulating factors present in MS.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-10-01 |