6533b7dcfe1ef96bd1271674
RESEARCH PRODUCT
Determination of alternative preservatives in cosmetic products by chromophoric derivatization followed by vortex-assisted liquid-liquid semimicroextraction and liquid chromatography.
Amparo SalvadorAlberto ChisvertPablo MirallesIlianna Vrouvakisubject
Detection limitAnalytePreservativeChromatographymedia_common.quotation_subject010401 analytical chemistryPreservatives Pharmaceutical02 engineering and technologyCosmeticsPhenylethyl Alcohol021001 nanoscience & nanotechnology01 natural sciencesCosmetics0104 chemical sciencesAnalytical Chemistrychemistry.chemical_compoundBenzoyl chloridechemistryPhenethyl alcoholSample preparation0210 nano-technologyDerivatizationmedia_commonChromatography Liquiddescription
An analytical method for the simultaneous determination of phenethyl alcohol, methylpropanediol, phenylpropanol, caprylyl glycol, and ethylhexylglycerin, which are used as alternative preservatives in cosmetic products, has been developed. The method is based on liquid chromatography with UV spectrophotometric detection after chromophoric derivatization with benzoyl chloride and vortex-assisted liquid-liquid semimicroextraction. Different chromatographic parameters, derivatization conditions, and sample preparation variables were studied. Under optimized conditions, the limits of detection values for the analytes ranged from 0.02 to 0.06µgmL(-1). The method was validated with good recovery values (84-118%) and precision values (3.9-9.5%). It was successfully applied to 10 commercially available cosmetic samples. The good analytical features of the proposed method besides of its environmentally-friendly characteristics, make it useful to carry out the quality control of cosmetic products containing the target compounds as preservative agents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 | Talanta |