6533b7dcfe1ef96bd1271bff

RESEARCH PRODUCT

Red Blood Cells Distribution Width as Biomarker of Worsening in Atherosclerosis

C. PianoCarmela Rita BalistreriP. NardiF. BertoldoA. PellegrinoR. MassoudG. Ruvolo

subject

red cell distribution width cardiovascular diseasecardiovascular diseasered cell distribution widthRDW CVD AtherosclerosisSettore MED/23 - Chirurgia Cardiaca

description

Red blood cell Distribution Width (RDW) is a parameter of the circulating erythrocytes’ size that it has reported to be associated with Cardiovascular Diseases (CVDs) [1-7]. The related mechanism of this association is not fully understood. However, RDW is an indicator of inflammation related to early inflammatory biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) [8,9]. Accordingly, systemic chronic inflammation leads to dysfunctional bone marrow with unsuccessful production of red blood cells [10]. As a result, it determines the migration of reticulocytes into the peripheral circulation, followed by an increase in circulating levels of immature Red Blood Cells (RBCs), as well as in higher RDW levels

yearjournalcountryeditionlanguage
2018-01-01
http://hdl.handle.net/10447/290259