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RESEARCH PRODUCT

Novel deoxycholic acid alkylamide-phenylurea-derived organogelators

Juha KoivukorpiErkki Kolehmainen

subject

Organic ChemistryDeoxycholic acidSupramolecular chemistryCarbon-13 NMRMass spectrometryBiochemistrychemistry.chemical_compoundMonomerchemistryChlorobenzeneDrug DiscoveryOrganic chemistryChirality (chemistry)Spectroscopy

description

Abstract Three monomeric and three dimeric deoxycholic acid (DCA) alkylamido-phenylurea derivatives are designed based on known gelators and are synthesized and characterized by 1 H and 13 C NMR spectroscopy, ESI-TOF mass spectrometry, and elemental analyses. Among them, a monomeric derivative forms supramolecular gels in CHCl 3 and chlorobenzene, whereas a dimeric derivative gels THF and higher 1-alkanols containing 7–10 carbons. The morphologies of their xerogels are studied by scanning electron microscopy (SEM). No signature of macroscopic chirality of the gels is visible.

yearjournalcountryeditionlanguage
2010-02-01Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2009.12.101