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RESEARCH PRODUCT

Possible transmission flow of SARS-CoV-2 based on ACE2 features

Antonio G. SoaresParise AdadiAdam BrufskyNima RezaeiNima RezaeiRamesh KandimallaKazuo TakayamaVladimir N. UverskyWagner Baetas-da-cruzShinjini GhoshGajendra Kumar AzadTarek Mohamed Abd El-azizTarek Mohamed Abd El-azizSamendra P. SherchanGaurav ChauhanMurat SeyranAlaa A. A. AljabaliDamiano PizzolPabitra Pal ChoudhuryMurtaza M. TambuwalaDiksha AttrishSk. Sarif HassanBruce D. UhalKenneth LundstromÁNgel Serrano-arocaGiorgio Palù

subject

chemistry.chemical_classificationCATSEnzymeCoronavirus disease 2019 (COVID-19)chemistryTransmission (medicine)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Cellular receptorBiologyReceptorVirologyhormones hormone substitutes and hormone antagonistsAmino acid

description

AbstractAngiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

yearjournalcountryeditionlanguage
2020-10-09
https://doi.org/10.1101/2020.10.08.332452