6533b7dcfe1ef96bd1271e88

RESEARCH PRODUCT

A multicenter observational study on Medication-Related Osteonecrosis of the Jaw (MRONJ) in advanced cancer and myeloma patients of a cancer network in North-Western Italy

Vittorio FuscoMarco CabrasFrancesco ErovigniAlessandro Dell?acquaPaolo-giacomo ArduinoMonica PenteneroPaolo AppendinoLorenzo BasanoFrancesco Della FerreraAntonella FascioloMajlinda CakaMario MigliarioStefano FranchiAlessio Gambino

subject

Malemedicine.medical_specialtyPopulation03 medical and health sciencescheek refinement0302 clinical medicineBreast cancerplasticInternal medicinemedicineCarcinomaHumanseducationGeneral DentistryUNESCO:CIENCIAS MÉDICASRetrospective Studiesbuccal fat padeducation.field_of_studyOral Medicine and PathologyBone Density Conservation AgentsDiphosphonatesbusiness.industryResearchIncidence (epidemiology)Cancer030206 dentistrymedicine.diseaseDenosumabZoledronic acidItalyOtorhinolaryngologyaestheticsfacial silhouette refiningbuccal fat pad excisionBisphosphonate-Associated Osteonecrosis of the JawSurgeryMultiple MyelomaOsteonecrosis of the jawbusinessmedicine.drug

description

Background Incidence of Medication-Related Osteonecrosis of the Jaw (MRONJ) related to cancer and myeloma treatments is undetermined, with scarce data varying from 2 to 7.8/million/year in limited investigated populations. A 9-years [2009-2018] regional-wide survey was conducted, deploying the North-Western Italy Cancer Network (“Rete Oncologica Piemonte e Valle d’Aosta”), to assess number and main characteristics of MRONJ cases among myeloma/cancer patients, within a population of 4.5 million inhabitants. Material and Methods MRONJ cases were collected retrospectively from January 2009 to June 2015; from July 2015 to December 2018, data were collected prospectively. Number of new MRONJ cases per year, underlying disorder, drug(s) administered, treatment duration, site and onset timing of MRONJ were detailed. Results 459 MRONJ cases were identified. Primary diseases were breast cancer (46%), prostate cancer (21%), myeloma (19%), and other types of carcinoma (14%). Patients received antiresorptive treatment either alone (399; 88.47%) or in combination with biological agents (52; 11.53%); 8 patients (1.7%) received only antiangiogenic drugs. Zoledronic acid [388] and denosumab [59] were the most frequently administered drugs. Mandible was involved in 296 (64,5%) cases. Number of new MRONJ cases was stable from 2009 to 2015, with a mean of 51.3 cases per year (raw incidence: 11.6/million/year), declining in the 2016-2018 years to 33.3 cases per year (raw incidence: 7.5/million/year). Conclusions With such discrepancy of cases overtime being partially explicable, number of new MRONJ cases per year are consistent with those observed in a previous study [2003-2008] in the same region, being instead higher than those reported in other populations. Key words:Osteonecrosis of the jaw, bisphosphonates, zoledronic acid, denosumab, antiangiogenic drug, incidence.

yearjournalcountryeditionlanguage
2020-09-15Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.24318