6533b7dcfe1ef96bd1271eb8
RESEARCH PRODUCT
A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland
Claudia ColombaRaffaella RubinoManlio TolomeoDavide Lo PortoSilvia BonuraStefano AgrenzanoAntonio Casciosubject
Emigrants and ImmigrantsDisseminated BCG infectionEmigrants and ImmigrantGeneral MedicinedeficiencyMicrobiologyNuclear FamilyInfectious DiseasesIFN-γR1VirologyPositron Emission Tomography Computed TomographyBCG VaccineHumansTuberculosisParasitologyFemaleChildTuberculosis.SwitzerlandHumandescription
Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis and contains a live, attenuated strain of Mycobacterium bovis as its essential constituent. Being a live, attenuated strain with potential pathogenicity, BCG can cause different complications, both near the inoculation site and through blood dissemination, especially in patients with immunodeficiency. IFN-γR1 deficiency is an autosomal recessively inherited immunodeficiency characterized by predisposition to infections with intracellular pathogens, in particular mycobacteria.
 We report a rare case of chronic osteomyelitis lasting 30 years due to BCG in a woman with IFN-γR1 deficiency who had previous clinical history of multi-organ BCGitis. Diagnosis of chronic osteomyelitis was confirmed by an 18-fluorine fluorodeoxyglucose positron emission tomography combined with CT scan (18F-FDG PET/CT).
 In children with a history of BCG vaccination and chronic unexplained infections, a clinical suspicion of BCG-related disease must arise, and a reason of immunodeficiency should be sought.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-02-28 |