Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

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RESEARCH PRODUCT

Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Anna Maria Campagna Enrico Carmina Roger A. Lobo Giustina Vitale Daniel H. Kort Pasquale Mansuet

subject

Adult Anti-Mullerian Hormone endocrine system medicine.medical_specialty Aging Settore MED/09 - Medicina Interna endocrine system diseases media_common.quotation_subject Settore MED/13 - Endocrinologia Body Mass Index Cohort Studies PCOS AMH Fertility Ovarian function Ovulation Aging Hyperandrogenism Predictive Value of Tests Internal medicine medicine Humans Prospective Studies Prospective cohort study Ovulation media_common Ultrasonography Antimullerian Hormone business.industry Ovary Obstetrics and Gynecology Middle Aged Polycystic ovary Settore MED/40 - Ginecologia E Ostetricia female genital diseases and pregnancy complications Endocrinology Reproductive Medicine Predictive value of tests Cohort Androgens Female Insulin Resistance business Body mass index Biomarkers Gonadotropins Cohort study Anovulation Polycystic Ovary Syndrome

description

Abstract OBJECTIVE: To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). DESIGN: Cohort. SETTING: Academic practice. PATIENT(S): A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects. INTERVENTION(S): Blood and ovarian ultrasound at baseline and after 5 years. MAJOR OUTCOME MEASURE(S): Serum antimüllerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound. RESULT(S): After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH ≤ 4 ng/mL was associated with ovulatory function. CONCLUSION(S): Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

year	journal	country	edition	language
2012-01-01	Fertility and sterility

10.1016/j.fertnstert.2012.06.017 https://pubmed.ncbi.nlm.nih.gov/22771030