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RESEARCH PRODUCT

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

Valeria FerraroMaria Letizia GarganoGiuseppe VenturellaFortunato Cirlincione

subject

Antifungalin vitro studymedicine.drug_classpharmaceutical propertieantitumor propertyChemistry PharmaceuticalReviewHealth benefitsimmunomodulationbiomoleculesCatalysislcsh:Chemistrydietary supplementsInorganic ChemistryBroad spectrumIn vivomedicineAnimalsHumansIn vitro studyPhysical and Theoretical Chemistrylcsh:QH301-705.5mycotherapyMolecular BiologySpectroscopyClinical Trials as TopicTraditional medicinemedicinal mushroomsbusiness.industrySettore BIO/02 - Botanica SistematicaOrganic Chemistryclinical trialGeneral Medicinebiomoleculemedicinal mushroomComputer Science ApplicationsClinical triallcsh:Biology (General)lcsh:QD1-999dietary supplementSettore BIO/03 - Botanica Ambientale E Applicatapharmaceutical propertiesAgaricalesbusiness

description

Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical studies are reported in this review. Besides, we analyzed the therapeutic use and pharmacological activities of mushrooms.

https://doi.org/10.3390/ijms22020634