CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes

6533b7dcfe1ef96bd1271f97

RESEARCH PRODUCT

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes

Giacomo Borgonovo Giuseppina Conteduca Samuele Tardito Silvia Stringara Giorgio Carmignani Gilberto Filaci Federico Ivaldi Alessia Parodi Francesca Ferrera Simonato Alchiede Florinda Battaglia Daniela Fenoglio Paolo Traverso Francesca Kalli Simone Negrini

subject

CD4-Positive T-Lymphocytes Cancer Research Immunology Antineoplastic Agents chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Biology T-Lymphocytes Regulatory Immune tolerance Antineoplastic Agent Lymphocytes Tumor-Infiltrating Immune system Antigen Antigens CD Immune Tolerance medicine Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Immunology and Allergy Cell Proliferation CD39 Tumor microenvironment Cell growth Apyrase Interleukin-2 Receptor alpha Subunit CD8-Positive T-Lymphocyte Tumor immune escape Phenotype Phenotype CD39 CD8+ Treg Tumor immune escape Tolerance Microscopy Fluorescence Oncology Mechanism of action CD4-Positive T-Lymphocyte Immunology CD8+ Treg medicine.symptom Tolerance CD8 Human

description

CD39 is an ectoenzyme, present on different immune cell subsets, which mediates immunosuppressive functions catalyzing ATP degradation. It is not known whether CD39 is expressed and implicated in the activity of CD8+ regulatory T lymphocytes (Treg). In this study, CD39 expression and function was analyzed in both CD8+ and CD4+CD25hi Treg from the peripheral blood of healthy donors as well as from tumor specimens. CD39 was found expressed by both CD8+ (from the majority of healthy donors and tumor patients) and CD4+CD25 hi Treg, and CD39 expression correlated with suppression activity mediated by CD8+ Treg. Importantly, CD39 counteraction remarkably inhibited the suppression activity of CD8+ Treg (both from peripheral blood and tumor microenvironment) suggesting that CD39-mediated inhibition constitutes a prevalent hallmark of their function. Collectively, these findings, unveiling a new mechanism of action for CD8+ Treg, provide new knowledge on intratumoral molecular pathways related to tumor immune escape, which could be exploited in the future for designing new biological tools for anticancer immune intervention. © 2013 Springer-Verlag Berlin Heidelberg.

year	journal	country	edition	language
2013-01-01	Cancer Immunology, Immunotherapy

https://doi.org/10.1007/s00262-013-1392-z