6533b7dcfe1ef96bd1272050

RESEARCH PRODUCT

Effects of immunosuppressive drugs on the cognitive functioning of renal transplant recipients: A pilot study

M Consuelo BernalJosé Vicente MontagudA. SanchoJosep CrespoSonia Martínez-sanchisGemma CandelaLuis M Pallardó

subject

AdultGraft RejectionMaleSleep Wake Disordersmedicine.medical_specialtyPilot ProjectsNeuropsychological TestsDevelopmental psychologyYoung AdultSurveys and QuestionnairesInternal medicinemedicineHumansNeuropsychological assessmentCognitive deficitPsychiatric Status Rating ScalesAnalysis of Variancemedicine.diagnostic_testCognitionMiddle AgedKidney TransplantationTacrolimusTransplantationClinical Psychologysurgical procedures operativeMoodNeurologySirolimusQuality of LifeKidney Failure ChronicAnxietyFemaleNeurology (clinical)medicine.symptomCognition DisordersPsychologyImmunosuppressive AgentsFollow-Up Studiesmedicine.drug

description

Some renal transplant patients show cognitive, emotional, and behavioral changes as part of possible neurotoxic effects associated with immunosuppressive medication, especially tacrolimus. This study evaluated effects of immunosuppressive drugs on some cognitive tasks. Patients treated with sirolimus and cyclosporine reported some of the noncognitive side effects related to immunosuppressive treatment. We observed attention and working memory impairment in patients treated with sirolimus or tacrolimus. Performance of cyclosporine-treated subjects was similar to that of healthy volunteer controls. Since the mood, anxiety, and sleep patterns measured were unaffected, it could be concluded that the cognitive deficit found was partly related to treatment.

yearjournalcountryeditionlanguage
2011-11-16Journal of Clinical and Experimental Neuropsychology
https://doi.org/10.1080/13803395.2011.595396