6533b7dcfe1ef96bd127208e

RESEARCH PRODUCT

Mechanisms of Ca2+ liberation at fertilization

Fabiana GeraciGiovanni Giudice

subject

MaleG proteinXenopusBiophysicsStimulationChick EmbryoFERTILIZATION CALCIUM RELEASEBiologyModels BiologicalBiochemistryReceptor tyrosine kinaseMiceHuman fertilizationGTP-Binding ProteinsAnimalsMolecular BiologySperm-Ovum InteractionsAdenine NucleotidesRyanodine receptorCell BiologySpermatozoaSpermCell biologyBiochemistryFertilizationbiology.proteinLiberationCalcium

description

The mechanisms underlying the Ca2+ release at fertilization of several animal organisms are reported. Four main classical theories are described, i.e., that of Ca2+ release following simple sperm contact and a G protein stimulation; that of simple sperm contact followed by a tyrosine kinase receptor activation; that of the necessity of introduction by sperm into the egg of molecules for Ca2+ release; and that the molecule introduced into the marine eggs for Ca2+ release is the same Ca2+. Two other mechanisms for Ca2+ release are also illustrated: that of ryanodine receptor stimulation and that of NAADP formation.

yearjournalcountryeditionlanguage
2005-09-01Biochemical and Biophysical Research Communications
https://doi.org/10.1016/j.bbrc.2005.06.103