Search results for "Liberation"

Optimization of the Hydrolysis of Safflower Oil for the Production of Linoleic Acid, Used as Flavor Precursor

2015

Commercial lipases, from porcine pancreas (PPL),Candida rugosa(CRL), andThermomyces lanuginosus(Lipozyme TL IM), were investigated in terms of their efficiency for the hydrolysis of safflower oil (SO) for the liberation of free linoleic acid (LA), used as a flavor precursor. Although PPL, under the optimized conditions, showed a high degree of hydrolysis (91.6%), its low tolerance towards higher substrate concentrations could limit its use for SO hydrolysis. In comparison to the other investigated lipases, Lipozyme TL IM required higher amount of enzyme and an additional 3 h of reaction time to achieve its maximum degree of SO hydrolysis (90.2%). On the basis of the experimental findings, C…

Corporealising a Healthy Democracy? Inequality, Bodies and Participation

2019

Socio-economic inequality is associated with differentiated levels of health and poor health affects political participation; inequalities are embodied in political life. This contribution, focusin...

Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases

2018

In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C-16, HA-EDA-C-16-PEG, and HA-EDA-C-16-CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C-16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinib-loaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process…

Mucoadhesive solid lipid microparticles for controlled release of a corticosteroid in the chronic obstructive pulmonary disease treatment.

2017

Therapeutic efficacy of inhaled drugs is limited by rapid clearance from the site of action due to absorption into systemic circulation or metabolic degradation by alveolar macrophages. Drug delivery systems offer new solutions to clinical problems especially in the treatment of pulmonary diseases. In particular, Solid Lipid Microparticles (SLM) in the range of 3-5 µm are suggested as systems for delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi, avoiding systemic absorption typical of alveolar regions. Here, we describe two novel different SLMs prepared with chitosan and alginate for sustained release of fluticasone propionate (…

Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.

2015

To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the nece…

Spanish Validation of the Polymorphous Prejudice Scale in a Sample of University Students

2016

ABSTRACTThe shortened version of the Polymorphous Prejudice Scale (PPS) analyzes new manifestations of prejudice toward gay men and lesbian women. Specifically, this instrument consists of 16 items distributed in four subscales: values gay progress, positive beliefs about gay men, positive beliefs about lesbian women, and resistance to heteronormative expectations. The aim of the current study is to add new evidence about the reliability and validity of the scale. The scale is administrated to 348 heterosexual university students from Spain with a mean age of 22.62 years (SD = 7.63). Reliability and factorial validity estimates are presented. A four-factor structure is supported using confi…

Prosodic modulation as a mark to express pragmatic values: The case of mitigation in Spanish

2021

Abstract One of the functions of prosody in discourse is to convey pragmatic values that add up to the core semantic meaning of spoken units or segments. Regarding mitigation, Caffi (1999: 890) specifically discusses “the very important prosodic and kinesic means of mitigation, such as changes in pitch prominence, rhythm, speech rate, as well as eye-contact, gaze, gaze aversion, smile, particular postures, etc.” In this paper, I focus on some prosodic factors such as pitch, intensity, duration and speech rate that can be used in European Spanish, in combination with pragmatic meanings. The first aim is to establish a theoretical deliberation on prosody as a clear marker to convey pragmatic …

Incivility in online news and Twitter: effects on attitudes toward scientific topics when reading in a second language

2021

Due to the participatory nature of Web 2.0, polite communication on social media and news sites can stand side by side with uncivil comments. Research on online incivility has been conducted with users reading in their mother tongues (L1), while the potential effects of incivility in a second language (L2) have been largely under- explored. This paper analyzes the effects of uncivil comments written in an L2 on attitudes around emerging technologies. Accordingly, study 1 replicates and extends a previous experiment on the effects of incivility to online news on risk perceptions of nanotechnology (Anderson et al., 2014), by adding an ‘L2 condition’ (uncivil comments written in an L2). Then, …

2018

Representative, legislative and deliberative assemblies are commonly called parliaments. The three types of assemblies share many procedures and practices, and the Inter-Parliamentary Union include...

Deliberation favours social efficiency by making people disregard their relative shares: evidence from USA and India

2017

Groups make decisions on both the production and the distribution of resources. These decisions typically involve a tension between increasing the total level of group resources (i.e. social efficiency) and distributing these resources among group members (i.e. individuals' relative shares). This is the case because the redistribution process may destroy part of the resources, thus resulting in socially inefficient allocations. Here we apply a dual-process approach to understand the cognitive underpinnings of this fundamental tension. We conducted a set of experiments to examine the extent to which different allocation decisions respond to intuition or deliberation. In a newly developed app…