6533b862fe1ef96bd12c6cbc
RESEARCH PRODUCT
Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.
Peter LangguthJozef Al-gousoussubject
030213 general clinical medicineDrug LiberationPharmaceutical Sciencechemistry.chemical_elementExcipientCalciumPharmacology030226 pharmacology & pharmacyDosage form03 medical and health scienceschemistry.chemical_compoundCalcium Chloride0302 clinical medicinemedicineSolubilityDosage FormsAspirinPhosphateEnteric coatingBioavailabilityDrug LiberationchemistrySolubilityTablets Enteric-Coatedmedicine.drugNuclear chemistrydescription
To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-01 | Journal of pharmaceutical sciences |