Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases

6533b871fe1ef96bd12d0efe

RESEARCH PRODUCT

Imatinib-Loaded Micelles of Hyaluronic Acid Derivatives for Potential Treatment of Neovascular Ocular Diseases

Giulia Di Prima Flavia Bongiovì Gaetano Giammona Gaetano Giammona Fabio Salvatore Palumbo Giovanna Pitarresi Calogero Fiorica

subject

0301 basic medicine Cell Survival Drug Compounding Pharmaceutical Science Administration Ophthalmic 02 engineering and technology Polyethylene glycol Micelle Permeability Cell Line Polyethylene Glycols Cornea 03 medical and health sciences chemistry.chemical_compound ocular drug delivery hyaluronic acid polymeric micelles imatinib transcorneal permeation ocular neovascular diseases Carnitine hemic and lymphatic diseases Drug Discovery Hyaluronic acid PEG ratio medicine ocular drug delivery; hyaluronic acid; polymeric micelles; imatinib; transcorneal permeation; ocular neovascular diseases Animals Humans Hyaluronic Acid Particle Size Protein Kinase Inhibitors neoplasms Micelles Drug Carriers Endothelial Cells Imatinib Permeation 021001 nanoscience & nanotechnology Ethylenediamines In vitro Choroidal Neovascularization Drug Liberation 030104 developmental biology chemistry Settore CHIM/09 - Farmaceutico Tecnologico Applicativo Biophysics Imatinib Mesylate Molecular Medicine lipids (amino acids peptides and proteins)Cattle Nanocarriers 0210 nano-technology medicine.drug

description

In this work, new micellar systems able to cross corneal barrier and to improve the permeation of imatinib free base were prepared and characterized. HA-EDA-C-16, HA-EDA-C-16-PEG, and HA-EDA-C-16-CRN micelles were synthesized starting from hyaluronic acid (HA), ethylenediamine (EDA), hexadecyl chains (C-16), polyethylene glycol (PEG), or L-carnitine (CRN). These nanocarriers showed optimal particle size and mucoadhesive properties. Imatinib-loaded micelles were able to interact with corneal barrier and to promote imatinib transcorneal permeation and penetration. In addition, a study was conducted to understand the in vitro imatinib inhibitory effect on a choroidal neovascularization process. Imatinib released from polymeric micelles was able to inhibit endothelial cell sprouting and to promote cell tube disruption.

year	journal	country	edition	language
2018-09-24

10.1021/acs.molpharmaceut.8b00620 http://www.scopus.com/inward/record.url?eid=2-s2.0-85054770046&partnerID=q2rCbXpz