6533b7dcfe1ef96bd1272170
RESEARCH PRODUCT
7-Nitroindazole blocks conditioned place preference but not hyperactivity induced by morphine.
Marta Rodríguez-ariasJosé MiñarroMaría A. AguilarMiguel NavarroC Manzanedosubject
Male7-NitroindazoleIndazolesRatónMale miceNitric Oxide Synthase Type IPharmacologyHyperkinesisMotor ActivityNitric oxideDevelopmental psychologyBehavioral Neurosciencechemistry.chemical_compoundMiceRewardmedicineAnimalsEnzyme InhibitorsbiologyDose-Response Relationship DrugMorphineConditioned place preferenceNitric oxide synthaseAnalgesics OpioidchemistryMorphinebiology.proteinConditioningConditioning OperantNitric Oxide Synthasemedicine.drugdescription
The effects of 7-nitroindazole (7-NI), a neural nitric oxide synthase (nNOS) inhibitor, on spontaneous locomotor activity, morphine-induced hyperactivity, acquisition of place conditioning and morphine-induced conditioned place preference (CPP) were evaluated in male mice. In experiment 1, animals treated with 7-NI (25, 50 and 100 mg/kg), morphine (40 mg/kg) or morphine (40 mg/kg) plus 7-NI (25, 50 or 100 mg/kg) were placed in an actimeter for 3 h. In experiment 2, animals treated with the same drugs and doses were conditioned following an unbiased procedure. 7-NI did not affect the spontaneous locomotor activity or hyperactivity induced by morphine. However, the moderate and high doses of 7-NI produced conditioned place aversion (CPA) and the lowest dose blocked morphine-induced CPP. Our results suggest that nitric oxide is involved in the rewarding properties of morphine but not in its motor effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-04-07 | Behavioural brain research |