6533b7dcfe1ef96bd127218b
RESEARCH PRODUCT
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones
Christophe PannecouqueAngela RaoErik De ClercqAlba ChimirriAnna CarboneAnna Maria MonforteMaria ZappalàPietro Monfortesubject
Anti hiv activityAnti-HIV activityAnti-HIV Agents23-Diaryl-13-thiazolidin-4-oneChemistryStereochemistryHuman immunodeficiency virus (HIV)Pharmaceutical ScienceGeneral MedicineVirus ReplicationRing (chemistry)medicine.disease_causeChemical synthesisIn vitroCell LineThiazoleschemistry.chemical_compoundHIV-2Drug DiscoveryHIV-1NNRTIsLactammedicineHumansdescription
Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a variously substituted phenyl ring at N-3 have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-01-01 | Il Farmaco |