6533b7dcfe1ef96bd12727fa

RESEARCH PRODUCT

Liver Membrane Autoantibodies

Ulrich TreichelKarl-hermann Meyer Zum Büschenfelde

subject

Liver diseaseImmune systemAntigenImmunologybiology.proteinmedicineAutoantibodyAsialoglycoprotein receptorBiologyAntibodyDifferential diagnosismedicine.diseaseIn vitro

description

Publisher Summary This chapter includes the intensive efforts to standardize the assay, define associations with disease or clinical presentation, and characterize antigenic and biological properties of anti-liver membrane antibodies. The characterization of different target antigens on the hepatic plasma membrane shows a polyvalent and heterogenous humoral immune response against the liver surface. Liver membrane antibodies can induce liver cell damage in vitro, including dysfunction of the target antigen. Among the established liver membrane-related autoantigens, the asialoglycoprotein receptor (ASGPR) represents the only component of the hepatic plasma membrane that is fully characterized. Assays for the detection of anti-ASGPR are reliable. The clinical data support the use of measuring anti- ASGPR for the differential diagnosis of patients with chronic inflammatory liver disease.

yearjournalcountryeditionlanguage
1996-01-01
https://doi.org/10.1016/b978-044482383-0/50072-8