6533b7dcfe1ef96bd12728c4

RESEARCH PRODUCT

Combinatorial solid-phase synthesis using D-galactose as a chiral five-dimension-deversity scaffold

Horst KunzTobias WunbergChristopher KallusStefan HenkeTill OpatzWolfgang Schmidt

subject

Scaffoldchemistry.chemical_compoundSolid-phase synthesisStereochemistryChemistryGalactoseOrganic ChemistryDrug DiscoveryDimension (graph theory)Side chainBiochemistryCombinatorial chemistry

description

Abstract All five hydroxy groups of galactose as the scaffold are used for selective coupling of side chains in a combinatorial methodology by application of a set of orthogonally stable protecting groups in combination with a thioglycoside anchor.

https://doi.org/10.1016/s0040-4039(99)01690-1