6533b7dcfe1ef96bd12728c8
RESEARCH PRODUCT
Enantiomerization of an inherently chiral resorcarene derivative: determination of the interconversion barrier by computer simulation of the dynamic HPLC experiment
Volker SchurigOliver TrappChristian SchmidtSalvatore CaccameseVolker Böhmersubject
ElutionOrganic ChemistryAnalytical chemistryForm analysisChiralpak ADResorcinareneChiral stationary phaseHigh-performance liquid chromatographyCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryPhysical and Theoretical ChemistryEnantioselective hplcDerivative (chemistry)description
Abstract The inherently chiral tetrabenzoxazine resorcarene derivative 1 shows characteristic plateau-formation during enantioselective HPLC separation on the chiral stationary phase Chiralpak AD. By computer assisted peak form analysis of the elution profiles, obtained from temperature dependent dynamic HPLC (DHPLC) experiments, with ChromWin, the enantiomerization barrier Δ G # (298 K)=92±2 kJ mol −1 and the activation parameters Δ H # =53.0±1.8 kJ mol −1 and Δ S # =−131±14 J (K mol) −1 were determined.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-06-01 | Tetrahedron: Asymmetry |