6533b7dcfe1ef96bd1272923
RESEARCH PRODUCT
A short synthesis of pyridines from deprotonated α-aminonitriles by an alkylation/RCM sequence
Till OpatzMarco M. NebeCarina WeberLukas P.v. Kaluzasubject
DeprotonationStevens rearrangementOlefin metathesis010405 organic chemistryChemistryStereochemistryGeneral ChemistryAlkylation010402 general chemistry01 natural sciences0104 chemical sciencesSequence (medicine)description
Abstract α-Aminonitriles can serve as versatile key precursors for the synthesis of nitrogen containing heterocycles. After unsuccessful trials involving the [1,2]-Stevens rearrangement of nitrile-stabilized ammonium ylides, we herein report a simple three-step synthesis of substituted pyridines based on an alkylation/ring-closing metathesis/aromatization sequence.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-04-12 | Zeitschrift für Naturforschung B |