6533b7dcfe1ef96bd1272962
RESEARCH PRODUCT
STAT6: its role in interleukin 4-mediated biological functions.
Shizuo AkiraKiyoshi TakedaTadamitsu Kishimotosubject
BiologyMediatorimmune system diseasesAntigens CDparasitic diseasesDrug DiscoveryAnimalsHumansskin and connective tissue diseasesGenetics (clinical)Interleukin 4STAT6Interleukin-13Interleukinhemic and immune systemsReceptors InterleukinIRS2Cell biologyReceptors Interleukin-4Interleukin 13ImmunologySTAT proteinTrans-ActivatorsMolecular MedicineInterleukin-4Signal transductionSTAT6 Transcription FactorSignal Transductiondescription
Interleukin (IL) 4 is known to be a cytokine which plays a central role in the regulation of immune response. Studies on cytokine signal transduction have clarified the mechanism by which IL4 exerts its functions. Two cytoplasmic proteins, signal transducer and activator of transcription (STAT) 6 and IL4-induced phosphotyrosine substrate/insulin receptor substrate 2 (4PS/IRS2), are activated in IL4 signal transduction. Recent studies from STAT6-deficient mice have revealed the essential role of STAT6 in IL4-mediated biological actions. In addition, STAT6 has also been demonstrated to be important for the functions mediated by IL13, which is related to IL4. IL4 and IL13 have been shown to induce the production of IgE, which is a major mediator in an allergic response. These findings indicate that STAT6 activation is involved in IL4- and IL13-mediated disorders such as allergy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-04-30 | Journal of molecular medicine (Berlin, Germany) |