6533b7dcfe1ef96bd12729a2
RESEARCH PRODUCT
Lack of Population Diversity in Commonly Used Human Embryonic Stem-Cell Lines
Petr DvorakNoah A. RosenbergSean J. MorrisonSean J. MorrisonTrevor J. PembertonKristina HarterJack T. MosherErkan Ozge BuzbasCarlos SimónChaolong Wangsubject
Genetics0303 health scienceseducation.field_of_studyDrug discoveryPopulationGeneral MedicineDiseaseComputational biologyBiologyPolymorphism Single NucleotideEmbryonic stem cellCell Line3. Good health03 medical and health sciences0302 clinical medicinePopulation GroupsHumansPopulation diversityeducationEmbryonic Stem Cells030217 neurology & neurosurgeryGenome-Wide Association Study030304 developmental biologydescription
To the Editor: Human embryonic stem-cell research may lead to new methods of drug discovery, insights into mechanisms of disease, and eventually, cellular therapies. The potential benefit to patient populations may depend partially on the diversity of the stem-cell lines that are available for research and clinical use. However, investigators have been unable to target their research to diverse subgroups of existing lines or to ensure the inclusion of lines from the human populations most relevant to their diseases of interest, because almost no information has been available on the human population origin of existing stem-cell lines. Therefore, with the . . .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-12-19 | New England Journal of Medicine |