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RESEARCH PRODUCT
IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.
Andy CroxfordVanja LazarevicAmit AwasthiBrian S. WilsonVijay K. KuchrooLorena Riol-blancoMeike MitsdoerfferMohamed OukkaMohamed OukkaAri WaismanLaurie H. Glimchersubject
T cellCD8 AntigensReceptors Antigen T-Cell alpha-betaImmunologyMice NudeMice TransgenicBiologyArticleImmunophenotypingInterferon-gammaMiceImmune systemAntigenCell MovementT-Lymphocyte SubsetsmedicineImmunology and AllergyAnimalsInterferon gammaListeriosisCells CulturedMice KnockoutEffectorTumor Necrosis Factor-alphaIntracellular parasiteInterleukin-17Receptors Antigen T-Cell gamma-deltaReceptors InterleukinCoculture TechniquesCell biologymedicine.anatomical_structureImmunologyCD4 AntigensInterleukin-23 Subunit p19Tumor necrosis factor alphaInterleukin 17Peritoneummedicine.drugdescription
AbstractIL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of γδ and double negative (DN) αβ T cells. These cells were rapidly recruited to the site of infection and produced large amounts of IL-17, IFN-γ, and TNF-α. Notably, DN T cells transferred into L. monocytogenes-infected RAG2−/− mice prevented bacterial growth, confirming their protective role against intracellular pathogens. Our results show that IL-23 regulates the function of IL-17–producing γδ and DN T cells, two essential components of the early protective immune response directed against intracellular pathogens.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-18 | Journal of immunology (Baltimore, Md. : 1950) |