6533b7dcfe1ef96bd1272aae

RESEARCH PRODUCT

Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects

Olga PortolésJose M. OrdovasAlejandro Pérez-fidalgoJosé I. GonzálezCarolina Ortega-azorínOscar ColtellDolores CorellaJudith B. Ramírez-sabioJosé V SorlíCarmen SaizRamon EstruchEva M. Asensio

subject

Genetic MarkersLeptinMale0301 basic medicineobesityCandidate genePopulation030209 endocrinology & metabolismGenome-wide association studySingle-nucleotide polymorphismBiologyGenetic polymorphismsleptinPolymorphism Single NucleotideFTO geneArticleMediterranean population03 medical and health sciencesSex Factors0302 clinical medicineLeptinasexHumansSNPgeneticsGenetic Predisposition to Diseaseeducationleptin receptorAgedGenetic associationGeneticseducation.field_of_studygenome-wide association studyNutrition and DieteticsLeptin receptorMediterranean RegionPolimorfisme genèticCross-Sectional Studies030104 developmental biologyCardiovascular DiseasesSpainObesitatFemaleheterogeneitypolymorphismsFood Science

description

Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating polymorphisms in candidate genes have been inconsistent, and, in addition, very few genome-wide association studies (GWAS) have been undertaken. Our aim was to investigate the genes and gene variants most associated with plasma leptin concentrations in a high-cardiovascular-risk Mediterranean population. We measured plasma leptin in 1011 men and women, and analyzed the genetic factors associated using three approaches: (1) Analyzing the single nucleotide polymorphisms (SNPs) reported in a GWAS meta-analysis in other populations (including an SNP in/near each of these LEP, SLC32A1, GCKR, CCNL, COBLL1, and FTO genes)

yearjournalcountryeditionlanguage
2019-11-13Nutrients
https://doi.org/10.3390/nu11112751