6533b7dcfe1ef96bd1272b0e
RESEARCH PRODUCT
Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016
Alessandro BisbanoArianna NeriM. ArghittuChironna MariaPaola VaccaAndrea CiammaruconiIrene Alessandra GalantiPaola BernaschiCaterina VocaleAnna Maria BarbuiAnna GiammancoRosella De NittisAntonella MencacciElisabetta PaganiPatrizia IsolaCecilia FazioPaola Stefanellisubject
0301 basic medicineSerotypeMaleCefotaximeinvasive bacterial infectionsEpidemiologymolecular methodsNeisseria meningitidismedicine.disease_causeDisease Outbreaks0302 clinical medicineGenotypemolecular method030212 general & internal medicinenational surveillance systemChildPhylogenyAged 80 and overSurveillanceNeisseria meningitidisitaly; neisseria meningitidis; capsular serogroup w; clonal complex 11; invasive bacterial infections; invasive meningococcal disease; molecular methods; national surveillance systeminvasive bacterial infectionMiddle Aged3. Good healthItalyChild PreschoolPopulation SurveillanceFemalePublic Healthmedicine.drugAdultAdolescentAntibiotic sensitivity030106 microbiologyBiologySerogroup03 medical and health sciencesYoung AdultNeisseria meningitidis Serogroup W-135VirologymedicineNeisseria meningitidiHumanscapsular serogroup WAgedWhole Genome Sequencinginvasive meningococcal diseaseEnvironmental and Occupational HealthPublic Health Environmental and Occupational HealthInfant NewbornInfantSequence Analysis DNAVirologyPenicillinMeningococcal Infectionsclonal complex 11capsular serogroup W; clonal complex 11; invasive bacterial infections; invasive meningococcal disease; Italy; molecular methods; national surveillance system; Neisseria meningitidis; Epidemiology; Public Health Environmental and Occupational Health; VirologyHajjRifampicindescription
In Italy, B and C are the predominant serogroups among meningococci causing invasive diseases. Nevertheless, in the period from 2013 to 2016, an increase in serogroup W Neisseria meningitidis (MenW) was observed. This study intends to define the main characteristics of 63 MenW isolates responsible of invasive meningococcal disease (IMD) in Italy from 2000 to 2016. We performed whole genome sequencing on bacterial isolates or single gene sequencing on culture-negative samples to evaluate molecular heterogeneity. Our main finding was the cocirculation of the Hajj and the South American sublineages belonging to MenW/clonal complex (cc)11, which gradually surpassed the MenW/cc22 in Italy. All MenW/cc11 isolates were fully susceptible to cefotaxime, ceftriaxone, ciprofloxacin, penicillin G and rifampicin. We identified the full-length NadA protein variant 2/3, present in all the MenW/cc11. We also identified the fHbp variant 1, which we found exclusively in the MenW/cc11/Hajj sublineage. Concern about the epidemic potential of MenW/cc11 has increased worldwide since the year 2000. Continued surveillance, supported by genomic characterisation, allows high-resolution tracking of pathogen dissemination and the detection of epidemic-associated strains.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 |