6533b7dcfe1ef96bd1272c5e

RESEARCH PRODUCT

Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths.

Carla Muñoz-antoliAlba CortésJ. Guillermo EstebanRafael Toledo

subject

0301 basic medicineHelminthiasisHelminthiasisBiologyHost-Parasite Interactions03 medical and health sciencesHuman health0302 clinical medicineImmune systemTh2 CellsImmunityHelminthsmedicineHelminthsAnimalsHumansDeveloping regionsIntestinal Diseases ParasiticTh1 Cellsmedicine.diseaseImmunity Humoral030104 developmental biologyInfectious DiseasesImmunologyNeglected tropical diseasesParasitologyTh1 response030215 immunology

description

Intestinal helminthiases affect millions of people worldwide, mainly in developing regions, where they cause a significant negative impact on human health and socioeconomic growth of affected populations. However, intestinal helminthiases are still among the most neglected tropical diseases. Protective immunity against intestinal helminths is associated with development of type 2 responses. Nevertheless, in some host–intestinal helminth combinations, local Th1 responses are initiated, inducing chronicity. The usage of helminth–mouse models is useful for elucidating the mechanisms behind the initiation of each type of response. Herein, the current knowledge on these topics is reviewed, paying particular attention to the earliest events of the immune cascade which eventually lead to either susceptibility or resistance to infection.

yearjournalcountryeditionlanguage
2017-04-06Trends in parasitology
10.1016/j.pt.2017.05.004https://pubmed.ncbi.nlm.nih.gov/28566191