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RESEARCH PRODUCT
Hsp60 in Inflammatory Disorders
Antonella Marino GammazzaGiovanni TomaselloAbdo JurjusAngelo Leonesubject
animal structuresbusiness.industryMultiple sclerosisfungichemical and pharmacologic phenomenaDiseasemedicine.diseasemedicine.disease_causecomplex mixturesInflammatory bowel diseaseAutoimmunityBiomarkerImmune systemHeat shock proteinImmunologymedicineHSP60businessdescription
Heat shock proteins (HSP) including HSP60 are immunogenic proteins shared by particular microbial agents and mammals. HSP60 has been implicated in multiple inflammatory disorders and autoimmune diseases mostly through its interactions with the immune system. Such diseases include inflammatory bowel disease, chronic obstructive pulmonary disease, Hashimoto’s thyroiditis, myasthenia gravis, multiple sclerosis and even atherosclerosis plaques among others. It is present in the cytosol, cell membrane, cell surface as well as in the extracellular space and in the circulation. As a super antigen, HSP60 has the dual role as an immunomodulator and as a biomarker, a node molecule in balance between health and disease. Deciphering the mechanisms of HSP60 interactions with the immune system could lead to the development of new therapeutic strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 |