6533b7dcfe1ef96bd12732c4
RESEARCH PRODUCT
Der Effekt von Neostigmin an der motorischen Endplatte beim Intermediärsyndrom der Alkylphosphatvergiftung
Roland Bessersubject
medicine.medical_specialtybiologybusiness.industryOrganophosphateNeuromuscular transmissionmedicine.diseaseOrganophosphate poisoningAcetylcholinesteraseNeostigminechemistry.chemical_compoundEndocrinologyMotor EndplatechemistryEnzyme inhibitorPhysiology (medical)AnesthesiaInternal medicinemedicinebiology.proteinNeurology (clinical)businessmedicine.drugCholinesterasedescription
A patient with severe organophosphate intoxication received Neostigmine 1 mg IV during the intermediate syndrome. This dose resulted clinically and neurophysiologically in a marked deterioration of neuro-muscular transmission. This effect of neostigmine on the neuromuscular block during the intermediate syndrome (deterioration) differs from its effect on a similar pattern (improvement), which is seen in the delayed neuropathy following organophosphate exposure. The administration of therapeutic doses of cholinesterase inhibitors in patients with a reduced safety margin due to inhibition of endplate acetylcholinesterase may be dangerous.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-03-01 | Klinische Neurophysiologie |