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RESEARCH PRODUCT
ChemInform Abstract: Synthesis of Elemane Bis-lactones Structurally Related to Vernolepin.
Begoña GarcíaGonzalo BlayLuz CardonaLuisa LahozJosé R. Pedrosubject
Terpenechemistry.chemical_classificationchemistry.chemical_compoundChemical transformationNatural productchemistryStereochemistryVernolepinHemiacetalGeneral MedicineRing (chemistry)LactoneSantonindescription
Abstract The chemical transformation of santonin into an elemane bis -lactone structurally related to the antitumour compound vernolepin is reported. The transformation of ring A of santonin into a hemiacetal δ-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obtained in this way revealed that the proposed structure for the natural product should be revised.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-20 | ChemInform |