Search results for "Vernolepin"

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ChemInform Abstract: Synthesis of Elemane Bis-lactones Structurally Related to Vernolepin.

2010

Abstract The chemical transformation of santonin into an elemane bis -lactone structurally related to the antitumour compound vernolepin is reported. The transformation of ring A of santonin into a hemiacetal δ-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obtained in this way revealed that the proposed structure for the natural product should be revised.

Terpenechemistry.chemical_classificationchemistry.chemical_compoundChemical transformationNatural productchemistryStereochemistryVernolepinHemiacetalGeneral MedicineRing (chemistry)LactoneSantoninChemInform
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Synthesis of elemane bis-lactones structurally related to vernolepin

1998

Abstract The chemical transformation of santonin into an elemane bis -lactone structurally related to the antitumour compound vernolepin is reported. The transformation of ring A of santonin into a hemiacetal δ-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obtained in this way revealed that the proposed structure for the natural product should be revised.

chemistry.chemical_classificationChemical transformationNatural productStereochemistryOrganic ChemistryNanotechnologyRing (chemistry)Biochemistrychemistry.chemical_compoundchemistryDrug DiscoveryVernolepinHemiacetalLactoneSantoninTetrahedron Letters
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