6533b827fe1ef96bd1286dbc
RESEARCH PRODUCT
Synthesis of elemane bis-lactones structurally related to vernolepin
Luz CardonaBegoña GarcíaGonzalo BlayJosé R. PedroLuisa Lahozsubject
chemistry.chemical_classificationChemical transformationNatural productStereochemistryOrganic ChemistryNanotechnologyRing (chemistry)Biochemistrychemistry.chemical_compoundchemistryDrug DiscoveryVernolepinHemiacetalLactoneSantonindescription
Abstract The chemical transformation of santonin into an elemane bis -lactone structurally related to the antitumour compound vernolepin is reported. The transformation of ring A of santonin into a hemiacetal δ-lactone was achieved in eleven steps. The spectroscopic characteristics of the synthetic product obtained in this way revealed that the proposed structure for the natural product should be revised.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-05-01 | Tetrahedron Letters |