6533b7dcfe1ef96bd127338d
RESEARCH PRODUCT
Decreased consumption of branched-chain amino acids improves metabolic health
Harpreet K. BrarRobert S. FigenshauNicole E. CummingsSebastian I. Arriola ApeloFrancesco SpeltaFrancesco SpeltaEmma L. BaarFaizan A. SyedTerri A. PietkaSara E. CottrellNicola VeroneseNicola VeroneseCaroline M. AlexanderDudley W. LammingJoshua C. NeumanBeatrice BertozziMatthew J. MerrinsArnold BullockRachel J. FenskeBrian A. SchmidtMichelle E. KimpleIldiko KaszaLuigi FontanaLuigi FontanaValeria TostiValeria TostiGerald L. AndrioleEdda CavaEdda Cavasubject
0301 basic medicineBlood GlucoseMalemedicine.medical_specialtyAdipose Tissue WhiteAdipose tissueBiologybranched-chain amino acids (BCAAs)General Biochemistry Genetics and Molecular BiologyArticle03 medical and health sciences0302 clinical medicineStress PhysiologicalInternal medicineInsulin-Secreting CellsGlucose IntolerancemedicineAnimalsHumansbiochemistryObesitylcsh:QH301-705.5Metabolic health2. Zero hungerchemistry.chemical_classificationgenetics and molecular biology (all)GluconeogenesisOrgan SizeMiddle Agedmedicine.diseaseObesityAmino acidFibroblast Growth FactorsMice Inbred C57BLProtein-restricted (PR)030104 developmental biologyEndocrinologyPharmacological interventionslcsh:Biology (General)BiochemistrychemistryGluconeogenesisDiet qualitybiochemistry; genetics and molecular biology (all)Dietary Proteins030217 neurology & neurosurgeryAmino Acids Branched-Chaindescription
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet. © 2016 The Authors
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 |