6533b7dcfe1ef96bd12733a8
RESEARCH PRODUCT
Enantioselective addition of nitromethane to α-keto esters catalyzed by copper(ii)–iminopyridine complexes
Victor Hernandez‐olmosGonzalo BlayJosé R. Pedrosubject
KetonePyridineschemistry.chemical_elementLigandsBiochemistryMedicinal chemistryCatalysisNitroparaffinsSubstrate SpecificityCatalysischemistry.chemical_compoundOrganic chemistryPhysical and Theoretical ChemistryAlkylchemistry.chemical_classificationCopper complexNitromethaneChemistryOrganic ChemistryEnantioselective synthesisEstersStereoisomerismCopperCarbonyl grouplipids (amino acids peptides and proteins)MethaneCopperdescription
The copper complex of a chiral iminopyridine easily prepared from (R)-(-)-fenchone and picolylamine catalyzes the enantioselective Henry (nitroaldol) reaction between nitromethane and alpha-keto esters. Good yields and modest to good enantioselectivities are obtained for a wide range of alpha-keto esters, bearing aromatic, alkyl or alkenyl groups attached to the ketone carbonyl group.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-26 | Org. Biomol. Chem. |