6533b7dcfe1ef96bd1273438

RESEARCH PRODUCT

Replication of fMRI group activations in the neuroimaging battery for the Mainz Resilience Project (MARP)

Alexandra SebastianKenneth S. L. YuenMiriam KampaAnita SchickOliver TüscherMichèle WessaRaffael Kalisch

subject

AdultMaleAdolescentIntraclass correlationCognitive Neurosciencemedia_common.quotation_subjectReplication050105 experimental psychologylcsh:RC321-571Task (project management)03 medical and health sciencesYoung Adult0302 clinical medicineNeuroimagingReplication (statistics)medicineHumans0501 psychology and cognitive sciencesFear conditioningLongitudinal StudiesGroup activationslcsh:Neurosciences. Biological psychiatry. Neuropsychiatrymedia_commonBrain Mappingmedicine.diagnostic_testfMRI05 social sciencesBrainReproducibility of ResultsExtinction (psychology)Resilience PsychologicalMagnetic Resonance ImagingNeurologyFemaleJaccard indexPsychological resiliencePsychologyFunctional magnetic resonance imagingIntra class correlation030217 neurology & neurosurgeryStress Psychologicalpsychological phenomena and processesReplication ; Group activations ; fMRI ; Intra class correlation ; Jaccard indexCognitive psychology

description

Abstract Motivated by the recent replicability crisis we tested replicability of functional magnetic resonance imaging (fMRI) group activations in two independent samples. An identical behavioral and fMRI test battery for the longitudinal investigation of stress resilience mechanisms was developed for the Mainz Resilience Project (MARP) and conducted in a discovery (N = 54) and a replication sample (N = 103). The test battery consisted of a stress reactivity task, a reward sensitivity task, a fear conditioning and extinction paradigm, two volitional reappraisal tasks and an emotional interference inhibition task. Replicability of group activations was tested with the Jaccard index and the Intra Class Correlation (ICC). Overall, we observed good to excellent replicability of activations at the whole brain level. Only a minority of contrasts showed unsatisfactory replicability. Replicability at the level of individual regions of interest (ROIs) was generally lower. Tasks with stronger activation in the discovery sample showed better replicability.

yearjournalcountryeditionlanguage
2020-01-01
10.1016/j.neuroimage.2019.116223https://www.sciencedirect.com/science/article/pii/S1053811919308146?via=ihub#appsec1