6533b7dcfe1ef96bd127350d
RESEARCH PRODUCT
Profile of leukocyte-endothelial cell interactions induced in venules and arterioles by nucleoside reverse-transcriptase inhibitors in vivo.
ÁNgeles ÁLvarezJosé E. PerisSamuel OrdenMaria D. BarrachinaJuan V. EspluguesCarmen De Pablosubject
Anti-HIV AgentsNeutrophilsIntercellular Adhesion Molecule-1Cell CommunicationPharmacologyEmtricitabineNucleoside Reverse Transcriptase InhibitorRats Sprague-DawleyVenulesAbacavirmedicineCell AdhesionImmunology and AllergyAnimalsHumansLeukocyte RollingDidanosineCells CulturedCD11b AntigenChemistryLamivudineEndothelial CellsIntercellular Adhesion Molecule-1VirologyDideoxynucleosidesRatsArteriolesDidanosineInfectious DiseasesCD18 AntigensLeukocytes MononuclearReverse Transcriptase InhibitorsEndothelium VascularNucleosideIntravital microscopymedicine.drugdescription
Background There is controversy regarding cardiovascular (CV) toxicity of the nucleoside reverse-transcriptase inhibitors used to treat human immunodeficiency virus infection. Methods We evaluated the effects of nucleoside reverse-transcriptase inhibitors on leukocyte-endothelium interactions, a hallmark of CV diseases, in rat mesenteric vessels using intravital microscopy and in human arterial cells using a flow chamber system. Results Abacavir and didanosine increased rolling, adhesion and emigration in rat vessels. These effects were reversed with antibodies against Macrophage-1 antigen (Mac-1) or intercellular adhesion molecule 1 and were reproduced in human cells. Lamivudine, zidovudine, emtricitabine, and tenofovir had no effects. Conclusions Our results support the association of abacavir and didanosine with CV diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-08-01 | The Journal of infectious diseases |