6533b7dcfe1ef96bd127353e
RESEARCH PRODUCT
Direct Metal‐ and Reagent‐Free Sulfonylation of Phenols with Sodium Sulfinates by Electrosynthesis
Joachim NiklSiegfried R. WaldvogelDieter SchollmeyerRobert FrankeSebastian Lipssubject
Green chemistrySodiumArylOrganic Chemistrychemistry.chemical_elementGeneral ChemistryElectrochemistryElectrosynthesisChemical synthesisCombinatorial chemistryCatalysisMetalchemistry.chemical_compoundchemistryvisual_artReagentvisual_art.visual_art_mediumdescription
A novel electrochemical strategy for the synthesis of aryl sulfones by direct sulfonylation of phenols with sodium sulfinates has been developed. The C,S-coupling products are of particular interest for chemical synthesis, material sciences and pharmaceutical sciences. By using this metal- and reagent-free electrochemical method, aryl and diaryl sulfones can be obtained directly in good yields. The established one-step protocol is easy to perform, scalable, inherently safe, and enables a broad scope, which is not limited by quinoid-forming substrates.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-02-24 | Chemistry – A European Journal |