6533b7ddfe1ef96bd12735d3
RESEARCH PRODUCT
Synthesis of polymeric derivatives of isoniazid: characterization and in vitro release from a water-soluble adduct with polysuccinimide.
Bianca CarlisiLibero Italo GiannolaGaetano Giammonasubject
Absorption of waterChemistryChemistry PharmaceuticalIsoniazidSuccinimidesGeneral ChemistryGeneral MedicineIn vitroAdductchemistry.chemical_compoundWater solubleEthanolamineSolubilityDrug DiscoverymedicineIsoniazidOrganic chemistryLipid bilayerTransfer rate constantmedicine.drugNuclear chemistrydescription
Coupling of isoniazid with polysuccinimide afforded a water-insoluble polymeric pro-drug; by reaction with ethanolamine it was chemically transformed in a water-soluble adduct. The in vitro release of isoniazid from the drug-polymer adduct was studied by using an artificial stomach wall lipid membrane. The transfer rate constant from simulated gastric juice to simulated plasma was defined and compared with that of an equivalent dose of pure drug.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-04-01 | Chemicalpharmaceutical bulletin |