6533b7ddfe1ef96bd127366c
RESEARCH PRODUCT
DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET-Optical Imaging
Bertrand BrizetBertrand BrizetClaire BernhardVictor GoncalvesFranck DenatPierre D. HarveyChristine Gozesubject
Boron CompoundsHalogenationPyridineschemistry.chemical_elementCatalysischemistry.chemical_compoundmedicineOrganic chemistrychemistry.chemical_classificationLuminescent Agentsmedicine.diagnostic_testLigand binding assayBiomoleculeOptical ImagingOrganic ChemistryGeneral ChemistryCombinatorial chemistrychemistryPositron emission tomographyAlkynesPositron-Emission TomographyClick chemistryFluorineBombesinClick ChemistryBODIPYLuminescencePreclinical imagingdescription
Several new boron dipyrromethene/N,N-dimethylaminopyridine (BODIPY-DMAP) assemblies were synthesized as precursors for bimodal imaging probes (optical imaging, OI/positron emission tomography, PET). The photophysical properties of the new compounds were also studied. The first proof-of-concept was obtained with the preparation of several new BODIPY-labeled bombesins and evaluation of the affinity for bombesin receptors by using a competition binding assay. Fluorination reactions were investigated on DMAP-BODIPY precursors as well as on DMAP-BODIPY-labeled bombesins. Chemical modifications on the BODIPY core were also performed to obtain luminescent dyes emitting in the therapeutic window (650-900 nm), suitable for in vivo imaging, making these compounds promising precursors for PET/optical dual-modality imaging agents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-02-26 | Chemistry - A European Journal |