Cilvēka zarnu mikrobioma salīdzinājums pacientiem ar dažādu 2.tipa cukura diabēta ilgumu un terapiju veidiem

6533b7ddfe1ef96bd127385e

RESEARCH PRODUCT

Cilvēka zarnu mikrobioma salīdzinājums pacientiem ar dažādu 2.tipa cukura diabēta ilgumu un terapiju veidiem

Ilze Izabella Dindune

subject

antidiabētiskā terapija zarnu mikrobioms metagenoms Bioloģija 2.tipa cukura diabēts

description

Maģistra darba izstrādes laikā iegūti rezultāti par zarnu mikrobioma taksonomiskā sastāva atšķirībām 270 pacientos ar 2. tipa cukura diabēta (T2D) diagnozi, bet atšķirīgu tā ilgumu kopš diagnosticēšanas brīža un pielietotajām antidiabētiskajām terapijām. Darba mērķis bija noskaidrot, kā šīm T2D pacientu apakšgrupām atšķiras zarnu mikrobioma taksonomiskais profils. Mikrobiālajai DNS, kas iegūta no fēču paraugiem, tika veikta visa metagenoma analīze ar lielapjoma paralēlo sekvenēšanu. Darba rezultāti apstiprināja vairākas zināmas asociācijas starp dažādām antidiabētiskajām terapijām un cilvēka zarnu mikrobiomu, kā arī iegūti jauni dati par zarnu mikrobioma taksonomiskajām atšķirībām indivīdos ar dažādu T2D stāžu un terapiju veidiem. Maģistra darbs tika izstrādāts no 2018. gada maija līdz 2021. gada maijam Latvijas Biomedicīnas pētījumu un studiju centrā.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54483

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