6533b7ddfe1ef96bd1273d91

RESEARCH PRODUCT

Phenotypic analysis of peripheral lymphocyte subpopulations in hydatid patients.

Amparo MirAna HernándezJ. Enrique O'connor

subject

AdultMalemedicine.medical_specialtyPathologyEchinococcosis HepaticHelminthiasischemical and pharmacologic phenomenaBiologyGastroenterologyNatural killer cellImmunophenotypingImmune systemAntigens CDT-Lymphocyte SubsetsInternal medicineparasitic diseasesmedicineHumansCystIL-2 receptorEchinococcus granulosusAgedGeneral VeterinaryGeneral MedicineT lymphocyteMiddle Agedmedicine.diseasebiology.organism_classificationInfectious Diseasesmedicine.anatomical_structureInsect ScienceLeukocytes MononuclearParasitologyFemaleCD8

description

Peripheral T-lymphocytes were analyzed in three groups of people: (1) individuals with current liver hydatid disease (hydatid patients, n = 20), (2) persons who had undergone surgical cyst removal at least 2 years previously (recovered patients, n = 9), and (3) a control group of healthy volunteers (uninfected controls, n = 13). Group 1 was subdivided according to cyst status, relapse of disease, and the presence or absence of symptoms. Percentages of lymphocytes expressing CD3, CD4, CD8, CD56, CD25, CD45RA, CD45RO, and HLA-DR were determined. Symptomatic patients had proportionally fewer CD3+ CD8 + lymphocytes than the control group (P=0.038). Hydatid patients with active cysts had proportionally more natural killer cells (CD56 + CD8-) than the control group (P = 0.028).

yearjournalcountryeditionlanguage
1999-09-24Parasitology research
10.1007/s004360050664https://pubmed.ncbi.nlm.nih.gov/10540959