6533b7ddfe1ef96bd1273e8b

RESEARCH PRODUCT

Vitamin D and the nervous system

Giulia BivonaCaterina Maria GambinoMarcello CiaccioGiorgia Iacolino

subject

0301 basic medicinecognitionMultiple SclerosisbrainDiseaseBioinformaticsCalcitriol receptorNervous Systemvitamin D deficiency03 medical and health sciences0302 clinical medicineMultiple SclerosimedicineVitamin D and neurologyHumansVitamin DVDRNeurodegenerative Diseasebusiness.industryMultiple sclerosisNeurodegenerative DiseasesGeneral Medicinemedicine.diseaseVitamin D Deficiencybehaviour030104 developmental biologyNeurologySchizophreniaAutismReceptors CalcitriolNeurology (clinical)Alzheimer's diseasebusiness030217 neurology & neurosurgeryHuman

description

Objective: to summarise the activities that Vitamin D (VD) carries out in the brain and to clarify the potential role of VD in neurological diseases. Methods: a literature research has been performed in Pubmed using the following keywords: 'Vitamin D', 'nervous system', 'brain'. Results: the studies reviewed show that VD contributes to cerebral activity in both embryonic and adult brain, helping the connectivity of neural circuits responsible for locomotor, emotional and reward-dependent behavior. Low VD serum levels have been found in patients affected by Alzheimer Disease, Parkinson Disease, Multiple Sclerosis, Autism Spectrum Disorders, Sleep Disorders and Schizophrenia. Discussion: findings are controversial and should be interpreted with caution, since most of the studies performed have observational study set and few interventional studies are available, producing conflicting results. Overall, it can be stated that the potential role of Vitamin D in neurological diseases is mostly unclear and further randomised controlled trials are needed to understand better whether Vitamin D supplementation treatment can be useful in brain disorders.

yearjournalcountryeditionlanguage
2019-05-30
10.1080/01616412.2019.1622872http://hdl.handle.net/10447/397660