6533b7ddfe1ef96bd1273f2a

RESEARCH PRODUCT

Biodegradable Protein Nanocontainers

Keti PiradashviliKeti PiradashviliFrederik R. WurmMichael FichterMichael FichterStephan GehringStephan GehringKatharina LandfesterKristin Mohr

subject

LysisPolymers and PlasticsBiocompatibilityHuman bloodProtein StabilityChemistryAlbuminBioengineeringNanotechnologyDendritic CellsBiomaterialsNanocapsulesAlbuminsDelayed-Action PreparationsBlood circulationProteolysisDrug deliveryMaterials ChemistryHumansHydrophobic and Hydrophilic InteractionsCells CulturedFluorescent Dyes

description

The application of synthetic polymers for drug delivery often requires tremendous efforts to ensure biocompatibility and -degradation. To use the body's own substances can help to overcome these problems. Herein, we present the first synthesis of nanocontainers entirely composed of albumin proteins. These protein nanocontainers (PNCs) were loaded with hydrophilic compounds and release of the payload is triggered through natural lysis in vitro in human monocyte-derived dendritic cells (moDCs). No aggregation of PNCs in human blood plasma was observed, indicating stability for blood circulation. As the PNCs were readily taken up by moDCs, they are considered as a promising delivery platform for vaccination strategies and could minimize the risk of side effects caused by foreign carrier substances.

yearjournalcountryeditionlanguage
2015-01-27Biomacromolecules
https://doi.org/10.1021/bm5016915