6533b7ddfe1ef96bd1273f5a
RESEARCH PRODUCT
Impaired refractory periods of peripheral sensory nerves in multiple sclerosis.
Hanns Christian HopfMagrit Eysholdtsubject
Adultmedicine.medical_specialtyPathologyMultiple SclerosisRefractory Period Electrophysiologicalbusiness.industryRefractory periodMultiple sclerosisSensory systemmedicine.diseaseNerve conduction velocityMedian nerveSurgeryPeripheralMedian NerveMyelinmedicine.anatomical_structureNeurologyRefractorymedicineHumansNeurology (clinical)Neurons AfferentPeripheral Nervesbusinessdescription
Maximum conduction velocity and relative refractory period (RRP) of median nerve sensory fibers were studied in 36 patients diagnosed as having multiple sclerosis (MS) and in 31 controls. Maximum conduction velocity did not differ in the two groups, but the RRP was significantly prolonged in MS patients. Increased RRP is observed mainly when peripheral nerve myelin is abnormal or damaged. Our findings support the assumption that peripheral nerve myelinated fibers are usually involved in MS.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1978-12-01 | Annals of neurology |