6533b7ddfe1ef96bd1273f74
RESEARCH PRODUCT
Cooling of the cerebellar interpositus nucleus abolishes somatosensory cortical learning-related activity in eyeblink conditioned rabbits.
Tapani KorhonenDavid G. LavondJan WikgrenTimo Ruusuvirtasubject
Cerebellumgenetic structuresEfferentCentral nervous systemSomatosensory system03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineHypothermia InducedEvoked Potentials SomatosensorymedicineAnimals030304 developmental biologyNeurons0303 health sciencesBrain MappingNeuronal PlasticityChemistryClassical conditioningAssociation LearningElectroencephalographyNeural InhibitionSignal Processing Computer-AssistedSomatosensory CortexEvoked Potentials MotorConditioning Eyelidmedicine.anatomical_structureEyeblink conditioningCerebellar NucleiFemaleNictitating membraneRabbitsNerve NetNeuroscienceNucleus030217 neurology & neurosurgerydescription
Nictitating membrane movement and multiple-unit activity in the somatosensory cortex were recorded from rabbits during paired (N = 6) and unpaired (N = 5) presentations of a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus (US). A behavioural conditioned response (CR) to the CS and an accompanying neural response in the somatosensory cortex developed only in the paired group. Inactivation of the cerebellar interpositus nucleus abolished both the acquired CR and the accompanying neural response. However, the CS facilitated both behavioural and neural responses to the US during the inactivation. Thus, the absence of the CR could not be accounted for by the general inability of the CS to alter the behaviour constituting the CR or the activity of the somatosensory cortex. These findings suggest that the efferent copy of the signal related to the eyeblink CR is projected from the cerebellum to the cerebral cortical areas of the US modality.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-11-15 | Behavioural brain research |