6533b7ddfe1ef96bd1273fca

RESEARCH PRODUCT

Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.

Alessandra MontalbanoRoberta LoddoAntonino LauriaChiara MusiuPaola BarrajaLaura SannaPatrizia DianaMaria Giovanna SetzuDonatella DelpianoFrancesco MingoiaAnna Maria Almerico

subject

PharmacologyModels MolecularMolecular modelChemistryStereochemistryAnti-HIV AgentsCell SurvivalOrganic ChemistryHuman immunodeficiency virus (HIV)HIV InfectionsGeneral Medicinemedicine.disease_causeChemical synthesisIn vitroVirusCell LinePhenanthridinesStructure-Activity RelationshipDrug DiscoverymedicineHIV-1HumansPyrrolesVolume concentration

description

Abstract The pyrrolo[1,2- f ]phenanthridines 8 – 22 and the corresponding non-rigid analogues 23 – 41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10 , 11 , and 13 showed a weak anti -HIV activity, whereas several pyrrolo-phenanthridines ( 8 , 10 , 16 – 18 ) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.

yearjournalcountryeditionlanguage
2002-02-14European journal of medicinal chemistry
10.1016/s0223-5234(01)01289-2https://pubmed.ncbi.nlm.nih.gov/11841870